Systemic, hereditary causes identified in pediatric bilateral cataract cases

[ad_1]

April 09, 2021

1 min read

Source:

Nihalani-Gangwani BR, et al. Systemic diagnoses in pediatric patients undergoing cataract surgery. Presented at: American Association for Pediatric Ophthalmology and Strabismus annual meeting; April 9-11, 2021 (virtual meeting).

Disclosures:
Nihalani-Gangwani reports no relevant financial disclosures. Please see the study for all other authors’ relevant financial disclosures.


We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected].

In children with bilateral cataracts, systemic and hereditary causes were more often identified than in unilateral cases, in which ocular associations were more often made, according to a study.

“There are few reports specifying associated systemic diagnoses in large cohorts of children undergoing cataract surgery,” Bharti R. Nihalani-Gangwani, MD, and colleague wrote in a poster presentation at the virtual American Association for Pediatric Ophthalmology and Strabismus annual meeting.

The researchers conducted a chart review of 727 patients younger than 21 years who underwent cataract surgery at a tertiary referral center during a 25-year period. Patients were classified by laterality and then further differentiated by systemic or ocular associations.

Cause of cataract was identified in 66% of patients in the bilateral cataract group and in 55% in the unilateral cataract group. Heredity causes (21.8%), syndromic/genetic/metabolic causes (23.8%) and treatment for cancer or systemic steroid treatment (14.7%) accounted for cataract in the majority of the 408 children with bilateral cataracts. Ocular dysmorphology drove most cases (48.9%) in the 319 children with unilateral cataract.

In the bilateral cases, Down syndrome (5.6%), Lowe syndrome (1.7%) and Marfan syndrome (4.2%) were the most prevalent systemic anomalies. The ocular associations most prevalent in unilateral cases were ocular trauma (20%), persistent fetal vasculature (19.5%) and retina or optic nerve anomalies (5.3%).

“Clinicians should be more aware of systemic diagnoses among children to guide systemic workup, provide framework for follow-up of such patients and for prediction of development of cataract in the fellow eye,” Nihalani-Gangwani and colleagues said.

[ad_2]

Source link

Elena Johaness

Leave a Reply

Your email address will not be published.