COVID-19 patients presenting with uveitis – ICMRJ



Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is an enveloped, positive sense, RNA virus, belonging to the family Coronaviridae, genus Betacoronavirus, was first identified and reported in Wuhan, the capital city of Hubei province in China, in December, 2019 and reported as the causative agents of the severe respiratory illness termed COVID-19.1 At the time of writing this paper there have been over 122 million confirmed COVID-19 cases, 98 million recovered, with over 2.7 million deaths globally.2 In Palestine, data obtained from the Palestinian ministry of health registration showed 230,609 confirmed COVID-19 cases, 205,920 recovered cases, and over 2449 deaths.3

Uveitis is an autoimmune disease of the eye that refers to any of a number of intraocular inflammatory conditions. It is reported that patients with uveitis who are taking high doses of corticosteroids and immunomodulatory therapies (IMT) are considered at high risk to get infected with severe COVID-19 disease.4,5 A case-series of 18 hospitalized patients identified SARS-CoV-2 RNA in tear samples in 28% of confirmed COVID-19 patients indicating that the respiratory tract is not the only transmission route.6 However, the absence of ocular signs in patients with positive tear samples imply that viral shedding in tears is not always related to ocular inflammation.7 Viral infection of the conjunctiva could induce a local immune or inflammatory response resulting in ocular manifestations. Cell-mediated immunity can play a major role in viral diseases in which infected cells in the uveal and corneal tissue have viral-specific antigens on their surface. Cell-mediated immunity can cause specific tissue damage, as in acute retinal necrosis. Various immune-regulatory cytokines (IL-6, IL-10, and IFN-γ) were detected in ocular fluid samples from patients with viral uveitis.8 Although the CD4+ T lymphocytes drive the disease during the course of experimental uveitis, the number of CD8+ T cells is increased indicating that uveitis is the result of much more than the aberrant activation of a single cell type.

Since March 2020, several papers have been published and stressed the risk of COVID-19 transmission among ophthalmologists due to the close contact between the physician and the patient during exam.9 Few papers reported conjunctivitis and uveitis in COVID-19 patients, but no cases were reported with findings suggesting that the patient could have been infected with COVID-19 and his eye condition lead to the diagnosis of COVID-19. Most reports mentioned eye complaints associated with COVID-19 including ocular surface disease (pain, redness, and photophobia), few stressed the risk of vision loss due to COVID-19.

We report three cases of COVID-19 patients with severe uveitis. These cases have not been reported previously and have been approved by the ethics committee of St John Eye Hospital (East Jerusalem, Palestine). All patients gave informed consent for the publication of their case details and any accompanying images. Herein, we stress on the importance of urgent ophthalmic assessment of any COVID-19 patient complaining of any eye symptoms (redness, pain, tearing, conjunctival swelling, blurred vision, pain with ocular movement), and highlight the professional role of ophthalmologists in managing COVID-19 patients with signs of uveitis.

Case 1

A 19‐year‐old male patient, with no significant past medical history, wearing glasses for myopia, presented to St John Eye Hospital complaining of both eyes redness and a blurred vision of one-month duration following recovery from COVID-19 (Table 1). The patient tested positive for SARS-CoV-2 by RT-PCR obtained from a nasopharyngeal swab on Dec 1, 2020 (Table 2). He was suffering from fever with a temperature of (41°C), cough, headache, joint pain, and skin rash (Table 1). One month later he developed pneumonia, he was treated as an outpatient by systemic oral antibiotics (azithromycine 500 mg daily for one week and oral dexamethasone (6 mg daily for five days). The patient started to complain of blurred vision, redness, and pain in both eyes five weeks post-positive PCR testing. At the initial examination on Jan 28, 2021, his best-corrected visual acuity was 6/18 in the right eye and 6/60 in his left eye. Slit‐lamp examination of the right eye showed conjunctival hyperemia, corneal edema and endothelial KPs (keratic precipitates), anterior chamber inflammatory cells with normal fundus examination. Left eye examination showed signs of more aggressive behavior with conjunctival hyperemia, corneal edema and kPs, anterior chamber hypopyon, iris deposits over the lens anterior capsule, clear vitreous, and normal fundus examination. Intraocular pressure measured with Goldmann tonometer was 13 mm Hg in both eyes. The patient was started on topical steroids (one drop/hour/daily in the first week then slowly tapered by decreasing one drop per day each week till stopping it,) systemic steroids (1 mg/kg) and cycloplegics, (cyclopentolate 1%). Laboratory tests to rule out other possible infectious or autoimmune diseases were performed and described in Table 2. The diagnosis of bilateral anterior uveitis secondary to COVID-19 infection was made. On his follow-up visit at the uveitis clinic on Feb 9, 2021, the patient showed a significant improvement, the best-corrected visual acuity was 6/12 in the right eye and 6/15 in the left eye, slit‐lamp examination revealed clinical improvement with white conjunctiva, clear cornea, and a quiet and deep anterior chamber. His last follow-up was on May 11, 2021, he is off medications with quiet eye examination and best corrected visual acuity (BCVA) 6/6 in both eyes.

Table 1 Systemic Symptoms, Ocular Findings, Classification of Uveitis and Given Medication

Table 2 Relevant Laboratory Tests

Case 2

A 29‐year‐old male patient, wearing glasses for myopia and astigmatism, presented to St John Eye Hospital on Jan 24, 2021 complaining of blurred vision in both eyes and pain of six weeks duration (Table 1), there was no history of joint pain, oral or genital ulcers, or skin rashes. Two months prior to his presentation, the patient suffered from fever, cough, and headache but he ignored his symptoms and did not seek any medical advice, neither PCR nor serology test for COVID-19 were done at that time. At the initial examination, his best-corrected visual acuity was 6/18 in both eyes. Slit‐lamp examination for both eyes showed vascular sheathing (Figure 1A), quiet anterior segment, minimal lens opacities, web-like vitreous veils with big white snowballs adherent to the vitreous webs (Figure 1B). Intraocular pressure measured with Goldmann tonometer was 13 mmHg in both eyes. The laboratory tests done for the patient are included in Table 2. Behçet’s disease was ruled out (no positive criteria in the history for all the scoring systems). The patient was subjected to COVID-19 antibody test (IgG), six weeks post-development of his viral symptoms, the test came back positive. The diagnosis of intermediate and posterior uveitis secondary to COVID-19 was made after excluding all other possible infectious and noninfectious causes.

Figure 1 Color fundus in right (A) and left (B) eyes of 29‐year‐old male COVID-19 patient demonstrating (A) vascular sheathing indicating vasculitis (B) RE web like vitreous veils indicating intermediate uveitis.

The patient was treated with prednisone 1 mg/kg for one week then tapered by 5 mg each week through his follow-up period, topical steroid pred forte (prednisolone acetate) was given every hour during the first week then tapered slowly. During his follow-up visits in February and March 2021, patient was doing well, his best-corrected visual acuity improved to 6/7.5 in both eyes. On April 8, 2021, the patient presented to the clinic with flare up in the right eye and increased vitreous opacity while he was on prednisone 5 mg daily. Leptospira immunoglobulin test was requested in April 2021—after the paper submission—but unfortunately is not available in Palestine and due to COVID-19 pandemic restrictions, we could not send him to do the test in nearby countries, However, he was discharged on prednisone 1 mg/kg, Imuran™ (azathioprine), steroid sparing agent was added. On May 6, 2021, the patient was on prednisone 20 mg daily, azathioprine 50 mg twice daily, with significant improvement upon examination.

Case 3

A 62‐year‐old male patient, with no significant past medical history and known ocular history of right eye primary angle-closure glaucoma controlled by COSOPT® eye drops (timolol 0.5%, dorzolamide 2%), He underwent right eye phacoemulsification and intraocular lens implantation on Nov 29, 2020, due to a right eye cataract. On Dec 28, 2020, he tested positive for COVID-19 by RT-PCR. He did not complain of any respiratory symptoms and all blood tests were normal (Table 2). The only complaint was recurrent attacks of right eye pain, redness, and blurred vision with no photophobia. He was referred to our uveitis clinic on Feb 5, 2021, for further investigations. At the initial examination, his best-corrected visual acuity was 6/9 in the right eye and 6/6 in his left eye. Slit‐lamp examination was remarkable for right eye mild conjunctival hyperemia, with multiple corneal keratic precipitates (KPs) (Figure 2, white arrow), and a deep anterior chamber with +4 cells (Figure 2, yellow arrows). Fundus examination revealed a clear vitreous and flat healthy retina. Intraocular pressure measured with Goldmann tonometer was 11 mmHg in both eyes. Under the diagnosis of right eye iridocyclitis mostly secondary to COVID-19 infection, the patient was treated with topical steroids (dexamethasone 1 mg/mL) one drop/hour/daily in the first week then slowly tapered by decreasing one drop per day each week till stopping it, cyclopentolate 1% was instilled three times daily for 1 week then stopped. Seven days later, the patient showed a significant improvement, the best-corrected visual acuity was 6/7.5 in the right eye, slit‐lamp examination revealed clinical improvement with white conjunctiva, clear cornea with few KPs, and a few cells in the anterior chamber. The plan was to stop cycloplegics, tapering steroids, and to continue his follow-up in the glaucoma clinic.

Figure 2 Slit‐lamp examination eyes of 62‐year‐old male COVID-19 patient demonstrating endothelial keratic precipitate (white arrow), cells in the anterior chamber indicating iridocyclitis (yellow arrows).


To the best of our knowledge, this is the first clinical report of bilateral intermediate and posterior uveitis due to COVID-19 (as seen in case 2). It is well known that SARS-CoV-2 induces conjunctivitis. A study conducted on 38 COVID-19 infected patients showed that 5% of them had virus-positive conjunctivitis and 32% had conjunctivitis.10 Moreover, retinal hemorrhages, central retinal vein occlusion and other retinal thrombotic complications have been observed in COVID-19 patients.11,12

Here, we described three cases of uveitis developing a few weeks after diagnosis of COVID-19, new mutations of the virus are still emerging which should raise red flags for possibly more severe complications and higher rates of infection. The COVID-19 pathophysiology is still not well understood as many factors affect the prognosis. Patients controlled with immunosuppressive medications showed milder degrees of inflammation than those who are not receiving any medication. Uveitis patients who are treated with systemic immunosuppression—to control ocular inflammation—are potentially at higher risk of COVID-19 infection.5,13 Current perspectives are to use corticosteroids at the minimum possible dose for autoimmune conditions in the absence of COVID-19.14 However, according to the World Health Organization (WHO) recommendations; systemic corticosteroids should be avoided in severe cases of COVID-19.15 A clinical trial conducted in the UK showed that low dose dexamethasone can reduce the mortality of COVID-19 patients.16 Yet, the international experts and specialists have controversial opinions regarding the use of corticosteroids in COVID-19 patients. As we described in case 1, a diagnosis of bilateral anterior uveitis secondary to COVID-19 infection was made in a 19‐year‐old male patient who suffered from pneumonia. The ocular findings of this patient improved following topical and systemic corticosteroid therapy which was tapered over a period of six weeks. A recent case report17 showed that early use of corticosteroids at a moderate dose for a short course may enhance recovery of a COVID-19 patient. In this context, we support timely and appropriate use of corticosteroids in COVID-19 cases taking into consideration uveitis severity, systemic comorbidities, age, and lens status. The diagnosis of bilateral intermediate and posterior uveitis was made in an apparently healthy man (case 2) with no previous systemic illnesses, upon his ocular findings of vascular sheathing as a sign of posterior uveitis, and peripheral inferior vitreous condensations (snowballs) as a sign of intermediate uveitis. Taking into consideration his viral prodromal symptoms prior to his eye disease made us think of infectious uveitis, while these days the pandemic is spreading enormously in Palestine, we asked the patient to do coronavirus IgG titer which returned positive, and all other tests returned negative leaving COVID-19 as the presumptive etiology for the inflammation. Intermediate and posterior uveitis warrant further evaluation with differential diagnosis supported by laboratory tests due to the association with systemic diseases and risk of permanent vision loss.

This case report described the significance of ocular symptoms which can be overlooked if patients do not show typical systemic symptoms of COVID-19. The cytokine storm is the leading side effect during cellular immunotherapy, which can be triggered by viral infections. By treating this patient, studying his presentation, we strongly stress the importance of detailed medical history of the patient. Alternatively, conjunctiva is considered as an important portal of entry for respiratory viruses, conjunctival secretions may contain virus and spread viral infection.18 The close proximity between patients and ophthalmologists during slit lamp examination may pose an infectious risk to ophthalmologists. In their study, Lai et al suggested a variety of control measures that may be adopted to reduce the risk of coronavirus transmission in ophthalmic facilities.13 Moreover, the American Academy of Ophthalmology has issued an important alert for ophthalmologists advising them to wear protective eye masks when seeing conjunctivitis patients with respiratory symptoms.19

In case 3, our patient had right eye cataract surgery one month prior to his COVID-19 confirmed illness, with previous ocular history of well-controlled glaucoma in his right eye. Our patient had well-controlled primary angle closure glaucoma for two years with topical antiglaucoma treatment but a few weeks after the surgery, he developed iridocyclitis as a consequence of COVID-19 infection. It is well known that people with preexisting health conditions are more vulnerable to infection and the efficacy of virus entry into host cells partially depends on the immune conditions of the host and the presence of ACE2 on host cell membrane.20 Previous reports showed that the human conjunctival, corneal and limbal epithelial cell, retina, respiratory tract, enterocytes of the small intestine, and the proximal tubules of the kidney share the same ACE2 receptors for COVID-19 virus.21 It is reported that a transmembrane serine protease (TMPRSS2) cleaves the S protein into S1 and S2 domains upon virus binding to ACE2 and thus enables fusion of the viral and host cellular membranes allowing the viral entry. Cornea is also considered a potential site for SARS-CoV-2 infection since co-expression of ACE2 and TMPRSS2 were reported in corneal epithelium and endothelium. However, ACE2 expression in ocular surface is much lower than in lung and kidney tissues as only 6.6% of cells of the superficial conjunctival epithelium express both entry proteins TMPRSS2 and ACE2.22,23 Hence, the ability of SARS-CoV spike protein to bind with conjunctival ACE2 is much lower than that in lung cells.24 Moreover, the tear film and the fast drainage may provide a barrier for infection of the underlying epithelia preventing the viral persistence and binding to the cornea and/or conjunctival epithelial receptors.25 Nevertheless, the potential for systemic transmission from the nasolacrimal duct cannot be ruled out.

During the pandemic, patients undergoing surgery should be closely followed-up and monitored to avoid any complication. The use of eye prophylaxis in our clinical practice protocol is highly recommended to prevent the spread of the virus through the ocular route of transmission. COVID-19 should be considered in the differential diagnosis while dealing with any patient suffering from eye complaints following surgery or being treated for previous ocular disease.

In conclusion, we presented ocular involvement in three COVID‐19 cases to emphasize the importance for the health-care providers to be aware of the possible inflammatory ocular manifestation during and after COVID‐19 infection. All physicians should keep in mind the possibility of uveitis in the differential diagnosis when dealing with patients who had previous viral prodromal symptoms up to a few weeks prior to presenting with uveitis.


The authors thank the patients who agreed to participate in this report.


The authors report no conflicts of interest and no financial support for this work.


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